Abstract
The highly syn-diastereo- and enantioselective direct vinylogous Michael addition ofα-thio substituted furanones with conjugate nitroalkenes was demonstrated using an axially chiral guanidine base catalyst. The method provides facile access to enantioenriched α,γ-functionalized butenolides that can be further manipulated, thereby rendering them useful synthetic intermediates.
Original language | English |
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Pages (from-to) | 2026-2029 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 13 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2011 Apr 15 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry