Enantioselective direct amination of α-cyanoacetates catalyzed by bifunctional chiral Ru and Ir amido complexes

Yasuharu Hasegawa; Masahito Watanabe; Ilya D. Gridnev; Takao Ikariya

doi:10.1021/ja710273s

Enantioselective direct amination of α-cyanoacetates catalyzed by bifunctional chiral Ru and Ir amido complexes

Yasuharu Hasegawa, Masahito Watanabe, Ilya D. Gridnev, Takao Ikariya

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

The bifunctional chiral amido Ir complex catalyzed asymmetric electrophilic direct amination of α-substituted α-cyanoacetates using azodicarboxylates proceeds rapidly to provide the corresponding hydrazine adducts in high yields and with excellent ee values.

Original language	English
Pages (from-to)	2158-2159
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	7
DOIs	https://doi.org/10.1021/ja710273s
Publication status	Published - 2008 Feb 20
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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title = "Enantioselective direct amination of α-cyanoacetates catalyzed by bifunctional chiral Ru and Ir amido complexes",

abstract = "The bifunctional chiral amido Ir complex catalyzed asymmetric electrophilic direct amination of α-substituted α-cyanoacetates using azodicarboxylates proceeds rapidly to provide the corresponding hydrazine adducts in high yields and with excellent ee values.",

author = "Yasuharu Hasegawa and Masahito Watanabe and Gridnev, {Ilya D.} and Takao Ikariya",

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AU - Hasegawa, Yasuharu

AU - Watanabe, Masahito

AU - Gridnev, Ilya D.

AU - Ikariya, Takao

PY - 2008/2/20

Y1 - 2008/2/20

N2 - The bifunctional chiral amido Ir complex catalyzed asymmetric electrophilic direct amination of α-substituted α-cyanoacetates using azodicarboxylates proceeds rapidly to provide the corresponding hydrazine adducts in high yields and with excellent ee values.

AB - The bifunctional chiral amido Ir complex catalyzed asymmetric electrophilic direct amination of α-substituted α-cyanoacetates using azodicarboxylates proceeds rapidly to provide the corresponding hydrazine adducts in high yields and with excellent ee values.

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JF - Journal of the American Chemical Society

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Enantioselective direct amination of α-cyanoacetates catalyzed by bifunctional chiral Ru and Ir amido complexes

Abstract

ASJC Scopus subject areas

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