Enantioselective approach to the steroid skeleton by conjugate addition of alkenylcopper-phosphine complexes. Total syntheses of estrone methyl ether and its 7-alkylated derivative

Takayuki Doi, Katsuya Shimizu, Takashi Takahashi, Jiro Tsuji, Keiji Yamamoto

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Enantioselective syntheses of estrone methyl ether and its 7-alkylated derivative by the conjugate addition of alkenylcopper-phosphine complexes and discussions for the diastereoselectivity in the intramolecular Diels-Alder reaction of the o-quinodimethane derivative on the basis of MM2 transition structure models are presented.

Original languageEnglish
Pages (from-to)3313-3316
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number23
DOIs
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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