TY - JOUR
T1 - Enantioselective and Z/E-selective conjugate addition of α-substituted cyanoacetates to acetylenic esters catalyzed by bifunctional ruthenium and iridium complexes
AU - Hasegawa, Yasuharu
AU - Gridnev, Ilya D.
AU - Ikariya, Takao
PY - 2010/10/25
Y1 - 2010/10/25
N2 - Metal-based catalysts: The title reaction provided the chiral adducts in high yields, excellent enantiomeric excess, and high Z/E selectivity. A combined NMR/DFT study revealed a key intermediate for the stereoselective reaction and a possible reaction mechanism (see the optimized transition-state structure).
AB - Metal-based catalysts: The title reaction provided the chiral adducts in high yields, excellent enantiomeric excess, and high Z/E selectivity. A combined NMR/DFT study revealed a key intermediate for the stereoselective reaction and a possible reaction mechanism (see the optimized transition-state structure).
KW - Acetylenic esters
KW - Asymmetric conjugate addition
KW - Bifunctional catalysts
KW - Density functional calculations
KW - Ruthenium
UR - http://www.scopus.com/inward/record.url?scp=78249246640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78249246640&partnerID=8YFLogxK
U2 - 10.1002/anie.201003585
DO - 10.1002/anie.201003585
M3 - Article
C2 - 20857471
AN - SCOPUS:78249246640
VL - 49
SP - 8157
EP - 8160
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 44
ER -