Abstract
(Chemical Equation Presented) Double interaction doesit: Highly enantio- and diastereoselective aza-ene-type reaction of glyoxylate with an enecarbamate is accomplished by using a binol-derived phosphoric acid catalyst (see scheme). DFT computational analysis revealed that two hydrogen bonds formed between the catalyst and the aldehyde are critical for the high enantioselectivity.
Original language | English |
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Pages (from-to) | 4122-4125 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 47 |
Issue number | 22 |
DOIs | |
Publication status | Published - 2008 May 19 |
Keywords
- Asymmetric catalysis
- Brønsted acids
- Ene reactions
- Phosphoric acids
- Transition states
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)