Enantioselective 1,4-addition reactions of diphenyl phosphite to nitroalkenes catalyzed by an axially chiral guanidine

Masahiro Terada, Takashi Ikehara, Hitoshi Ube

Research output: Contribution to journalArticlepeer-review

116 Citations (Scopus)

Abstract

A highly enantioselective 1,4-addition reaction of nitroalkenes with diphenyl phosphite was successfully accomplished using a newly developed axially chiral guainidine catalyst. A broad range of nitroalkenes, bearing not only aromatic but also aliphatic substituents, is applicable to the present enantioselective reaction. The method provides an efficient protocol to synthesize enantioenriched β-amino phosphonate derivatives of biological and pharmaceutical importance.

Original languageEnglish
Pages (from-to)14112-14113
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number46
DOIs
Publication statusPublished - 2007 Nov 21

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint

Dive into the research topics of 'Enantioselective 1,4-addition reactions of diphenyl phosphite to nitroalkenes catalyzed by an axially chiral guanidine'. Together they form a unique fingerprint.

Cite this