Enantioseiective aryiative cyclization of allenyl aldehydes with arylboronic acids under Pd(II)-diphosphine catalysis

Hirokazu Tsukamoto, Tomotaka Matsumoto, Yoshinori Kondo

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

A Pd(OAc)2-SEGPHOS combination catalyzes the first enantioseiective aryiative cyclization of allenyl aldehydes with aryiboronic acids to provide c/s-fused fiveand six-membered cyclic homoallylic alcohols. The excellent diastereoand enantioselectivity and the fact that the reaction proceeds at room temperature in the absence of any additives make the process highly practical.

Original languageEnglish
Pages (from-to)1047-1050
Number of pages4
JournalOrganic letters
Volume10
Issue number6
DOIs
Publication statusPublished - 2008 Mar 20

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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