Enantiopure trans- and cis-3-Aminoindan-1-ols: Preparation and application as novel basic resolving agents

Kazushi Kinbara, Yoshiyuki Katsumata, Kazuhiko Saigo

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

trans- and cis-3-Aminoindan-1-ols were prepared by moderately selective reductions of 3-aminoindan-1-one derivatives and separated into enantiopure forms. The enantiopure trans-isomer had a moderate resolving ability for 2-arylalkanoic acids having a naphthalene ring at the α-position. The X-ray crystallographic analysis showed that an infinite hydrogen-bond sheet was formed in the less-soluble salt, suggesting that the skeleton of these indanols would be favorable for the stabilization of the less-soluble salt by hydrogen-bonding interaction.

Original languageEnglish
Pages (from-to)266-267
Number of pages2
JournalChemistry Letters
Issue number3
DOIs
Publication statusPublished - 2002 Mar 5

ASJC Scopus subject areas

  • Chemistry(all)

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