TY - JOUR
T1 - Emerging roles of the FBW7 tumour suppressor in stem cell differentiation
AU - Wang, Zhiwei
AU - Inuzuka, Hiroyuki
AU - Fukushima, Hidefumi
AU - Wan, Lixin
AU - Gao, Daming
AU - Shaik, Shavali
AU - Sarkar, Fazlul H.
AU - Wei, Wenyi
PY - 2012/1
Y1 - 2012/1
N2 - FBW7 is a ubiquitin E3 ligase substrate adaptor that targets many important oncoproteins-such as Notch, c-Myc, cyclin E and c-Jun-for ubiquitin-dependent proteolysis. By doing so, it plays crucial roles in many cellular processes, including cell cycle progression, cell growth, cellular metabolism, differentiation and apoptosis. Loss of FBW7 has been observed in many types of human cancer, and its role as a tumour suppressor was confirmed by genetic ablation of FBW7 in mice, which leads to the induction of tumorigenesis. How FBW7 exerts its tumour suppression function, and whether loss of FBW7 leads to de-differentiation or acquisition of stemness-a process frequently seen in human carcinomas-remains unclear. Emerging evidence shows that FBW7 controls stem cell self-renewal, differentiation, survival and multipotency in various stem cells, including those of the haematopoietic and nervous systems, liver and intestine. Here, we focus on the function of FBW7 in stem cell differentiation, and its potential relevance to human disease and therapeutics.
AB - FBW7 is a ubiquitin E3 ligase substrate adaptor that targets many important oncoproteins-such as Notch, c-Myc, cyclin E and c-Jun-for ubiquitin-dependent proteolysis. By doing so, it plays crucial roles in many cellular processes, including cell cycle progression, cell growth, cellular metabolism, differentiation and apoptosis. Loss of FBW7 has been observed in many types of human cancer, and its role as a tumour suppressor was confirmed by genetic ablation of FBW7 in mice, which leads to the induction of tumorigenesis. How FBW7 exerts its tumour suppression function, and whether loss of FBW7 leads to de-differentiation or acquisition of stemness-a process frequently seen in human carcinomas-remains unclear. Emerging evidence shows that FBW7 controls stem cell self-renewal, differentiation, survival and multipotency in various stem cells, including those of the haematopoietic and nervous systems, liver and intestine. Here, we focus on the function of FBW7 in stem cell differentiation, and its potential relevance to human disease and therapeutics.
KW - FBW7
KW - Notch
KW - c-Jun
KW - differentiation
KW - stem cell
UR - http://www.scopus.com/inward/record.url?scp=84555189751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84555189751&partnerID=8YFLogxK
U2 - 10.1038/embor.2011.231
DO - 10.1038/embor.2011.231
M3 - Review article
C2 - 22157894
AN - SCOPUS:84555189751
VL - 13
SP - 36
EP - 43
JO - EMBO Reports
JF - EMBO Reports
SN - 1469-221X
IS - 1
ER -