Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol

Kumiko Makide, Hajime Kitamura, Yusuke Sato, Michiyo Okutani, Junken Aoki

Research output: Contribution to journalReview articlepeer-review

83 Citations (Scopus)

Abstract

It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G-protein-coupled receptors. Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo. On the other hand, other LPLs such as lysophosphatidylserine (LPS), lysophosphatidylthreonine (LPT), lysophosphatidylethanolamine (LPE), lysophosphatidylinositol (LPI) and lysophosphatidylglycerol (LPG) have been reported to show lipid mediator-like responses both in vivo (LPS and LPT) and in vitro (LPS, LPT, LPE and LPG), while very little is known about their receptor, synthetic enzyme and patho-physiological roles. In this review, we summarize the actions of these LPLs as lipid mediators including LPS, LPT, LPE and LPG.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalProstaglandins and Other Lipid Mediators
Volume89
Issue number3-4
DOIs
Publication statusPublished - 2009 Sep

Keywords

  • Enzyme
  • Lysophospholipids
  • Receptor

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

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