Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus

Yurika Ikeda-Dantsuji, Hideaki Hanaki, Taiji Nakae, Yoshio Takesue, Kazunori Tomono, Junichi Honda, Katsunori Yanagihara, Hiroshige Mikamo, Kunihiko Fukuchi, Mitsuo Kaku, Shigeru Kohno, Yoshihito Niki

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21 Citations (Scopus)

Abstract

Methicillin-resistant Staphylococcus aureus with a MIC of linezolid of 4 μg/ml, isolated from a patient who had undergone unsuccessful linezolid therapy, yielded linezolid-resistant mutants in blood agar at 48 h of incubation. The resistant clones showed a MIC of linezolid ranging from 8 to 64 μg/ml and accumulated the T2500A mutation(s) of the rRNA genes. Emergence of these resistant clones appears to be facilitated by a cryptic mutation or mutations associated with chloramphenicol resistance.

Original languageEnglish
Pages (from-to)2466-2468
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume55
Issue number5
DOIs
Publication statusPublished - 2011 May

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Ikeda-Dantsuji, Y., Hanaki, H., Nakae, T., Takesue, Y., Tomono, K., Honda, J., Yanagihara, K., Mikamo, H., Fukuchi, K., Kaku, M., Kohno, S., & Niki, Y. (2011). Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 55(5), 2466-2468. https://doi.org/10.1128/AAC.01548-10