Elimination of Intracellular Bacteria by Autophagy

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Autophagy functions to eliminate several types of intracellular bacteria. Autophagy acts as the front line of innate immunity due to its rapid response to infection, but the mechanism of its induction is complicated. Upon infection of host cells by intracellular bacteria, autophagosomes form by targeting and recruiting the factors required to surround the bacteria. Several targeting pathways have been identified, including the ubiquitin-dependent pathway, the bacterial sensor-dependent pathway, and the damaged vacuole- dependent pathway, each of which functions through adapter proteins for autophagosome recruitment. Here we describe these pathways and discuss their role in the elimination of invasive bacteria.

Original languageEnglish
Title of host publicationAutophagy
Subtitle of host publicationCancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
PublisherElsevier Inc.
Pages203-210
Number of pages8
Volume3
ISBN (Electronic)9780124055346
ISBN (Print)9780124055292
DOIs
Publication statusPublished - 2014 Jan 31

Keywords

  • Intracellular Bacteria
  • LRSAM1
  • Pattern Recognition Receptors (PRRs)
  • Peptidoglycan Recognition Proteins (PGRPs)
  • Toll-Like Receptor (TLR)
  • Ubiquitination

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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