Elevation of histidine decarboxylase activity in skeletal muscles and stomach in mice by stress and exercise

Kentaro Ayada, Makoto Watanabe, Yasuo Endo

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The effects of different types of stress (water bathing, cold, restraint, and prolonged walking) on histidine decarboxylase (HDC) activity in masseter, quadriceps femoris, and pectoralis superficial muscles, and in the stomach were examined in mice. All of these stresses elevated gastric HDC activity. Although water bathing, in which muscle activity was slight, was sufficiently stressful to produce gastric hemorrhage and to increase gastric HDC activity, it produced no detectable elevation of HDC activity in any of the muscles examined. The other stresses all elevated HDC activity in all three muscles. We devised two methods of restraint, one accompanied by mastication and the other not. The former elevated HDC activity in the masseter muscle, but the latter did not. These results suggest that 1) HDC activity in the stomach is an index of responses to stress, 2) the elevation of HDC activity in skeletal muscles during stress is induced partly or wholly by muscle activity and/or muscle tension, and 3) stress itself does not always induce an elevation of HDC activity in skeletal muscles.

Original languageEnglish
Pages (from-to)R2042-R2047
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume279
Issue number6 48-6
DOIs
Publication statusPublished - 2000

Keywords

  • Histamine
  • Masseter muscle
  • Mastication
  • Temporomandibular disorders

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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