Elevated levels of nitric oxide in synovial fluid from patients with temporomandibular disorders

Tetsu Takahashi, Toshirou Kondoh, Kazutoshi Kamei, Hiroshi Seki, Masayuki Fukuda, Hirokazu Nagai, Hiroshi Takano, Yoshiyuki Yamazaki

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Objective. The objective of this study was to measure nitric oxide activity in synovial fluid samples taken from patients with temporomandibular disorders. Study design. We investigated six volunteers without symptoms and 56 patients with temporomandibular disorders. Nitric oxide activity was measured in temporomandibular joint synovial fluid with a highly sensitive and specific chemiluminescence detection method. Results. A detectable nitrite concentration was found in only 1 of 10 joints in the control group. Measurable levels (>0.001 mol/l) of nitrites in the synovial fluid were found in 8 (72.7%) of 11 joints with disk derangement with clicking, 24 (85.7%) of 28 joints with disk derangement with locking, and all 26 (100%) joints with osteoarthritis. The mean nitrite concentrations in the temporomandibular joint synovial fluid in the disk derangement with clicking, disk derangement with locking, and osteoarthritis groups were significantly higher than that in the control group (p < 0.05, p < 0.001, p < 0.001, respectively. Conclusions. These data clearly show increased nitric oxide production in certain temporomandibular disorders and suggest that nitric oxide may play a role in the pathogenesis of synovitis and degenerative changes of cartilaginous tissue and bone of the temporomandibular joint.

Original languageEnglish
Pages (from-to)505-509
Number of pages5
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Issue number5
Publication statusPublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)


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