Elevated immunoreactive-adrenomedullin levels in the aqueous humor of patients with uveitis and vitreoretinal disorders

Tetsuo Udono, Kazuhiro Takahashi, Toshiaki Abe, Shigeki Shibahara, Makoto Tamai

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

To clarify possible involvement of adrenomedullin in the pathophysiology of inflammation of eyes, we measured immunoreactive-adrenomedullin concentrations in the aqueous humor and plasma obtained from 14 control subjects and 56 patients with uveitis or vitreoretinal disorders. Immunoreactive-adrenomedullin levels in the aqueous humor were significantly elevated in patients with active uveitis, proliferative vitreoretinopathy and proliferative diabetic retinopathy, as compared with control subjects. The plasma immunoreactive-adrenomedullin levels were not significantly correlated with the aqueous humor levels. These findings suggest that adrenomedullin produced locally in the eyes is involved in the pathophysiology of uveitis and some proliferative vitreoretinal disorders.

Original languageEnglish
Pages (from-to)1865-1868
Number of pages4
JournalPeptides
Volume23
Issue number10
DOIs
Publication statusPublished - 2002 Oct 1

Keywords

  • Adrenomedullin
  • Eye
  • Retina
  • Retinal detachment
  • Uveitis
  • Vitreous

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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