Elevated cerebrospinal fluid tau protein level as a predictor of dementia in memory-impaired individuals

H. Arai, T. Nakagawa, Youichi Kosaka, M. Higuchi, T. Matsui, N. Okamura, M. Tashiro, H. Sasaki

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

In order to investigate whether measurement of cerebrospinal fluid tau (CSF-tau) protein levels serves to detect Alzheimer's disease (AD) in its incipient stages, the CSF-tau levels were examined in 15 memory-impaired, but non-demented individuals. In 10 patients who later progressed to develop AD, the entry CSF-tau levels were significantly increased compared to five patients who remained non-demented during follow-up. Elevated CSF-tau levels may therefore serve as a predictor of progression to dementia consistent with AD.

Original languageEnglish
Pages (from-to)211-213
Number of pages3
JournalAlzheimer's Research
Volume3
Issue number5
Publication statusPublished - 1997 Jan 1

Keywords

  • Alzheimer's disease
  • Biological marker
  • Cerebrospinal fluid
  • Early diagnosis
  • Tau protein

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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