Elevated adrenomedullin in the vitreous of patients with proliferative vitreoretinopathy

Tetsuo Udono, Kazuhiro Takahashi, Shoko Takano, Shigeki Shibahara, Makoto Tamai

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

PURPOSE: To explore the possible involvement of adrenomedullin in the pathophysiology of proliferative vitreoretinopathy. METHODS: The radioimmunoassay technique was used to determine immunoreactive adrenomedullin concentrations in the vitreous fluid from 41 eyes of 41 patients undergoing vitrectomy for a variety of retinal conditions, including proliferative vitreoretinopathy, proliferative diabetic retinopathy, age- related macular degeneration, and macular hole. RESULTS: Immunoreactive adrenomedullin levels in the vitreous of patients with proliferative vitreoretinopathy were significantly higher than those of patients with proliferative diabetic retinopathy (P < .005), age-related macular degeneration (P < .001), and macular hole (P < .0001). CONCLUSION: Adrenomedullin may be involved in the pathophysiology of proliferative vitreoretinopathy.

Original languageEnglish
Pages (from-to)765-767
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume128
Issue number6
DOIs
Publication statusPublished - 1999 Dec 1

ASJC Scopus subject areas

  • Ophthalmology

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