Electroconvulsive shock increases serotonin transporter in the rat frontal cortex

Hao Wei Shen, Yohtaro Numachi, Sumiko Yoshida, Ko Fujiyama, Shigenobu Toda, Shuichi Awata, Hiroo Matsuoka, Mitsumoto Sato

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The antidepressive action of electroconvulsive shock (ECS) is thought to involve the alteration in serotonin (5-HT) neurotransmission, including the increase in 5-HT release and uptake. In our previous study, 5-HT transporter (5-HTT) mRNA expression was decreased after single and repetitive ECS in rat raphe nucleus. In the present study, we investigated the effects of single and repetitive ECS on the protein levels of 5-HTT in the frontal cortex, hippocampus and raphe nucleus of rat brain using quantitative Western blot analysis. Single ECS did not alter 5-HTT protein expression in any brain regions examined. Repetitive ECS stably increased 5-HTT protein in the frontal cortex, but not in the hippocampus and raphe nucleus. Because ECS is known to facilitate the release of neurotransmitters, our results suggest that the increased 5-HTT protein expression in the frontal cortex might be a compensatory change against the enhanced 5-HT release by ECS in presynaptic terminals.

Original languageEnglish
Pages (from-to)170-172
Number of pages3
JournalNeuroscience Letters
Issue number2
Publication statusPublished - 2003 May 1


  • Electroconvulsive shock
  • Frontal cortex
  • Hippocampus
  • Raphe nucleus
  • Serotonin transporter
  • Western blotting

ASJC Scopus subject areas

  • Neuroscience(all)


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