Electrochemical studies of danthron and the DNA-danthron interaction

Hui Zhou, Ziyi Sun, Tomonori Hoshi, Yoshitomo Kashiwagi, Jun Ichi Anzai, Genxi Li

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Danthron is an important natural occurring component in laxative drugs. In this paper, electrochemical investigation of danthron and its interaction with DNA is reported. Via the electrochemical approach assisted by ultraviolet-visible (UV-Vis) spectroscopy, we have proved that danthron intercalates into DNA strands forming some nonelectroactive complexes, which results in the decrease of redox peak currents of danthron. In addition, the decrease of the peak currents is proportional to the concentration of DNA. The difference between the interaction of danthron with double-stranded DNA (dsDNA) and with single-stranded DNA (ssDNA) has also been studied. This character implies the potential of danthron to discriminate dsDNA and ssDNA.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalBiophysical Chemistry
Volume114
Issue number1
DOIs
Publication statusPublished - 2005 Apr 1

Keywords

  • DNA
  • Danthron
  • Electrochemistry
  • Intercalation
  • UV-Vis spectroscopy

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Organic Chemistry

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