Electrochemical responses of catecholamines at a cyclodextrin monolayer-modified electrode

Electrode reactions of catecholamines were investigated by employing a gold electrode covered with a monolayer of a cyclodextrin derivative (1), which was prepared from bis (ω-carboxyundecyl) disulfide and 6-amino-6-O-deoxy- β-cyclodextrin. The electrode reaction of L-DOPA was mostly prevented by a 1-monolayer at the surface of a gold electrode. On the other hand, the electrode reactions of dopamine, norepinephrine, epinephrin still maintained about 50-30% of their original values when compared with corresponding anodic peak currents. Combining the results on the electrode reactions of ferrocene derivatives at the 1-monolayer modified electrode, we considered that the 1-monolayer would recognize the presence or absence of the carboxyl group in catecholamines.