Electrochemical printing of calcium alginate/gelatin hydrogel

Noriko Taira, Kosuke Ino, Jordan Robert, Hitoshi Shiku

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Here, we report the electrochemical printing of calcium-alginate (Ca-alginate)/gelatin hydrogel. The printing process involves placing an electrode within or above a gelatin hydrogel containing sodium alginate and CaCO3 particles. Owing to acidification resulting from water electrolysis at the electrode, Ca2+ is released from the CaCO3 particles, resulting in the formation of a Ca-alginate hydrogel within the gelatin. By scanning a probe electrode or by placing patterned electrodes in the desired locations, the hydrogel formation reaction could be made to occur at any location, with the formed Ca-alginate hydrogel being trapped within the gelatin, which acted as a supporting scaffold. Upon heating, the untreated gelatin melted, yielding patterned Ca-alginate/gelatin hydrogels. In addition, mammalian cells could be cultured successfully within the hydrogel. Finally, by stacking layers of the patterned hydrogel sequentially, three-dimensional (3D) hydrogel printing could be achieved. This method of electrochemical hydrogel printing has significant potential for use in the construction of 3D tissue organs.

Original languageEnglish
Pages (from-to)429-436
Number of pages8
JournalElectrochimica Acta
Volume281
DOIs
Publication statusPublished - 2018 Aug 10

Keywords

  • 3D printing
  • Calcium alginate hydrogel
  • Cell culture
  • Electrodeposition
  • Hydrogel printing

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Electrochemistry

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