Abstract
(Graph Presented) To each his own: An addressable electrochemical device consisting of orthogonally arranged rows and columns of electrodes has been constructed to monitor protein expression in genetically engineered cells at the single-cell level. The response based on redox cycling reflected the different expression levels of the enzyme from individual HeLa cells transfected with a plasmid vector including secreted alkaline phosphatase.
Original language | English |
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Pages (from-to) | 2044-2046 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 48 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2009 Mar 2 |
Keywords
- Biosensors
- Electrochemistry
- High-throughput screening
- Microelectrodes
- Single-cell analysis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)