Electrochemical gene-function analysis for single cells with addressable microelectrode/microwell arrays

Zhenyu Lin, Yasufumi Takahashi, Tatsuya Murata, Michiaki Takeda, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

(Graph Presented) To each his own: An addressable electrochemical device consisting of orthogonally arranged rows and columns of electrodes has been constructed to monitor protein expression in genetically engineered cells at the single-cell level. The response based on redox cycling reflected the different expression levels of the enzyme from individual HeLa cells transfected with a plasmid vector including secreted alkaline phosphatase.

Original languageEnglish
Pages (from-to)2044-2046
Number of pages3
JournalAngewandte Chemie - International Edition
Volume48
Issue number11
DOIs
Publication statusPublished - 2009 Mar 2

Keywords

  • Biosensors
  • Electrochemistry
  • High-throughput screening
  • Microelectrodes
  • Single-cell analysis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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