Electrochemical Determination of D-Glucose Using Nortropine-N-oxyl under Physiological Conditions

Katsuhiko Sato, Tetsuya Ono, Kentaro Yoshida, Toshinori Ito, Yoshitomo Kashiwagi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Nortropine-N-oxyl (NNO) was synthesized in a single step from nortropine. The electrocatalytical activity of NNO was evaluated by cyclic voltammetry in pH7.0 phosphate buffer solution. The anodic peak current for ethanol, isopropanol and glucose was enhanced, showing these alcohols were oxidized by electrocatalytic effect of NNO. On the other hand, TEMPO derivative (4-hydroxy-2,2,6,6,-terramethylpiperidine N-oxyl free radical) could not oxidize the alcohols under the same condition. The electrochemical response of the NNO to glucose was investigated. The anodic peak current increased with an increase in the concentration of glucose. A linear response to the glucose concentration ranging from 0.1 to 10mM was obtained.

Original languageEnglish
Pages (from-to)2272-2274
Number of pages3
Issue number10
Publication statusPublished - 2015 Oct


  • Diabetes treatment
  • Electrocatalytic oxidation
  • Mediator
  • Nitroxyl radical

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry


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