Electrochemical decomposition of layer-by-layer thin films composed of TEMPO-modified poly(acrylic acid) and poly(ethyleneimine)

Shigehiro Takahashi, Yu Aikawa, Tomotaka Kudo, Tetsuya Ono, Yoshitomo Kashiwagi, Jun Ichi Anzai

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The decomposition of layer-by-layer (LbL) thin films composed of 2,2,6,6-tetramethylpiperidine-1-oxyl free radical-appended poly(acrylic acid) (TEMPO-PAA) and poly(ethylenimine) (PEI) was studied by using a quartz crystal microbalance (QCM) and cyclic voltammetry. The electrode potential of the (PEI/TEMPO-PAA)4/PEI film-coated Au resonator was scanned from +0.2 to +0.8 V vs Ag/AgCl. The CV showed that the oxidation peak current decreased as the number of scans increased. The change in the resonance frequency of the QCM increased after electrolysis, indicating that the film was decomposed by electrolysis. The positive charges originating from the oxoammonium ions probably destabilized the (PEI/TEMPO-PAA)4/PEI film. Furthermore, the release of 5,10,15,20-tetraphenyl-21H,23H-porphine tetrasulfonic acid (TPPS) from TPPS-loaded (PEI/TEMPO-PAA)4/PEI-coated ITO electrodes was investigated. TPPS was released at electrode potentials greater than +0.6 V by the decomposition of the film. The results suggest that TEMPO-PAA/PEI LbL films are suitable for electrochemically controlled drug delivery systems.

Original languageEnglish
Pages (from-to)771-776
Number of pages6
JournalColloid and Polymer Science
Issue number3
Publication statusPublished - 2014 Mar


  • Drug delivery system
  • Electrochemistry
  • Layer-by-layer thin film
  • TEMPO-modified polymer

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry
  • Materials Chemistry


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