The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [ 18F]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [ 18F]fluoride was introduced into a disposable microfluidic cell (16μL) under an electric potential (10V), followed by anhydrous MeCN. The trapped [ 18F]fluoride was released in MeCN containing Kryptofix ® 222-KHCO 3 (ca. 60μL) under heat and a reversed potential (-2.5V). An automated module provided the [ 18F]fluoride ready for subsequent microfluidic radiosynthesis in overall radiochemical yields of 60% within 6min.
- Electrochemical concentration
- Fluorine-18 fluoride
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