Electrochemical concentration of no-carrier-added [ 18F]fluoride from [ 18O]water in a disposable microfluidic cell for radiosynthesis of 18F-labeled radiopharmaceuticals

Hidekazu Saiki, Ren Iwata, Hiroaki Nakanishi, Rebecca Wong, Yoichi Ishikawa, Shozo Furumoto, Ryo Yamahara, Katsumasa Sakamoto, Eiichi Ozeki

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [ 18F]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [ 18F]fluoride was introduced into a disposable microfluidic cell (16μL) under an electric potential (10V), followed by anhydrous MeCN. The trapped [ 18F]fluoride was released in MeCN containing Kryptofix ® 222-KHCO 3 (ca. 60μL) under heat and a reversed potential (-2.5V). An automated module provided the [ 18F]fluoride ready for subsequent microfluidic radiosynthesis in overall radiochemical yields of 60% within 6min.

Original languageEnglish
Pages (from-to)1703-1708
Number of pages6
JournalApplied Radiation and Isotopes
Volume68
Issue number9
DOIs
Publication statusPublished - 2010 Sep 1

Keywords

  • Automation
  • Electrochemical concentration
  • Fluorine-18 fluoride
  • Microfluidics

ASJC Scopus subject areas

  • Radiation

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