Electrochemical bio-lithography for controlling bionic interfaces

Research output: Contribution to conferencePaperpeer-review

1 Citation (Scopus)

Abstract

We have developed a novel technique, Electrochemical Biolithography, which enables in situ cellular micropatterning by electrochemical means. The cytophobic feature of the albumin-coated substrate was found to be switched to cell-adhesive by dilute HBrO electrogenerated at the tip of Pt-microelectrode approached closely to the substrates surface. Our patterning technique using the microelectrode is applicable to a pre-cell-patterned surface and thus enables the multi-micropatterning with different types of cell populations. Also the in situ control of cell growth and migration has been achieved. In addition, the technique is simple enough to be integrated to the small and closed systems such as microfluidic devices. The resulting cellular micropatterns on a single cell level have been characterized by electrochemical and photochemical means as a pharmacological model of cellular networks.

Original languageEnglish
Pages577-583
Number of pages7
Publication statusPublished - 2005 Dec 13
EventNanoscale Devices, Materials, and Biological Systems: Fundamental and Applications - Proceedings of the International Symposium - Honolulu, HI, United States
Duration: 2004 Oct 32004 Oct 8

Other

OtherNanoscale Devices, Materials, and Biological Systems: Fundamental and Applications - Proceedings of the International Symposium
CountryUnited States
CityHonolulu, HI
Period04/10/304/10/8

ASJC Scopus subject areas

  • Engineering(all)

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