Electrocatalytic oxidation of NADH by ferrocene derivatives and the influence of cyclodextrin complexation

Tomokazu Matsue, Masayuki Suda, Isamu Uchida, Tetsuya Kato, Uichi Akiba, Tetsuo Osa

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92 Citations (Scopus)

Abstract

The electrocatalytic oxidation of NADH by ferrocene derivatives and the influence of the complexation reaction of β-cyclodextrin (β-CD) were investigated in a buffered solution (pH 7.0). From the cyclic voltammetric behaviour, the electron-transfer rate constants from NADH to the ferricinium species were determined. The relationship between the rate constant and the half-wave potential demonstrated that the one-electron reaction of the NADH/NADH.+ couple is 1.02 V (vs. SHE). The deprotonation rate constant of NADH.+ was also estimated to be 6×106 s-1. The addition of β-CD accelerated the apparent reaction rate. However, analysis of the behaviour with ferrocenecarboxylic acid (FCA) suggested that the electron-transfer rate from NADH to the oxidized FCA in β-CD was three-tenths of that expected from the fully diffusion-controlled reaction.

Original languageEnglish
Pages (from-to)163-173
Number of pages11
JournalJournal of Electroanalytical Chemistry
Volume234
Issue number1-2
DOIs
Publication statusPublished - 1987 Sep 25

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemical Engineering(all)
  • Electrochemistry

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