Electro- and magneto-encephalographic spike source localization of small focal cortical dysplasia in the dorsal peri-rolandic region

Hisashi Itabashi, Kazutaka Jin, Masaki Iwasaki, Eiichi Okumura, Akitake Kanno, Kazuhiro Kato, Teiji Tominaga, Ryuta Kawashima, Nobukazu Nakasato

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: Small focal cortical dysplasia (FCD) may be ambiguous or overlooked on magnetic resonance (MR) imaging. Source localization of EEG and magnetoencephalography (MEG) spikes was evaluated to confirm the diagnosis of small FCD. Methods: This study included 6 epilepsy patients with a single small lesion on MR imaging suggesting FCD within a single gyrus among 181 consecutive epilepsy patients admitted to our epilepsy monitoring unit over 27. months. Stereotypical interictal spikes were detected on simultaneous EEG and MEG recordings and the onset-related source of averaged spikes was estimated. Results: All 6. patients had unique clinical characteristics as follows: leg sensori-motor seizures in 5. patients and eye version in 1. patient; a small MR imaging lesion suggesting FCD in the dorsal peri-rolandic region, which had been overlooked until our evaluation; and both EEG and MEG dipoles were estimated adjacent to the MR imaging lesion. Conclusions: Source localization of EEG and MEG spikes can confirm the diagnosis of FCD based on a single small MR imaging lesion, which was overlooked by previous examination of MR images. Significance: Examination of MR images should be based on spike source localization as well as seizure semiology to identify subtle MR imaging abnormalities.

Original languageEnglish
Pages (from-to)2358-2363
Number of pages6
JournalClinical Neurophysiology
Volume125
Issue number12
DOIs
Publication statusPublished - 2014

Keywords

  • EEG
  • Focal cortical dysplasia
  • Magnetic resonance imaging
  • Magnetoencephalography
  • Sensori-motor seizure
  • Source localization

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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