Electrical stimulation with a needle-type electrode inserted into the optic nerve in rabbit eyes

Hirokazu Sakaguchi, Takashi Fujikado, Hiroyuki Kanda, Makoto Osanai, Xiaoyun Fang, Kazuaki Nakauchi, Yasushi Ikuno, Motohiro Kamei, Masahito Ohji, Tetsuya Yagi, Yasuo Tano

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Purpose: To investigate whether electrical stimulation of the optic nerve can elicit an electrical evoked potential (EEP) in rabbits and to determine whether such stimulation is a useful approach for the placement of a visual prosthesis. Methods: Two needle-type electrodes were inserted into the optic nerve using a transvitreal approach. For electrical stimulation, monophasic and biphasic pulses were used. By stimulating the optic nerve, the EEP was elicited. After evaluation of the EEP, a histological study was carried out. Results: When electrical stimulation was applied, the EEP could be recorded. The threshold with monophasic and biphasic stimulation was 10 ± 0 μA and 20 ± 8.2 μA, respectively. Histological examination revealed no major complications, such as bleeding or degeneration, which might have resulted from the insertion of electrodes or the electrical stimulation. Conclusions: Electrical stimulation of the optic nerve can elicit an EEP, suggesting that this approach may be useful for a visual prosthesis system.

Original languageEnglish
Pages (from-to)552-557
Number of pages6
JournalJapanese Journal of Ophthalmology
Volume48
Issue number6
DOIs
Publication statusPublished - 2004 Nov

Keywords

  • Electrical evoked potential
  • Electrical stimulation
  • Electrode
  • Optic nerve
  • Visual prosthesis

ASJC Scopus subject areas

  • Ophthalmology

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