Efficient Use of Early Transition Metal, Titanium: Highly Selective Titanium Reagents

Koichi Mikami, Masahiro Terada, Takeshi Nakai

Research output: Contribution to journalArticle

12 Citations (Scopus)


The recent progress of highly selective titanium reagents in organic synthesis is reviewed. The use of titanium reagents is classified into the following six categories: (1) Bi-metallic reagents of titanium and main group elements, aluminum in particular, for olefination. (2) Alkyltitanium reagents for carbon-carbon bond formation. (3) Titanium enolates for aldol condensation. (4) Chiral titanium complexes for asymmetric Lewis-acid catalysis. (5) Low valent titanium reagents for reductive coupling reaction. (6) Sharpless reagent for asymmetric epoxidation.

Original languageEnglish
Pages (from-to)566-574
Number of pages9
JournalJournal of Synthetic Organic Chemistry, Japan
Issue number6
Publication statusPublished - 1991 Jan 1
Externally publishedYes


  • Alkyltitanium reagents
  • Asymmetric catalysis
  • Chemoselectivity
  • Chiral titanium complexes
  • Coupling reaction
  • Diastereoselectivity
  • Diels-Alder reaction
  • Enantios-electivity
  • Ene reaction
  • Hetero bi-metallic reagents
  • Hydroalumination
  • Hydromagnesiation
  • Hydrotitanation
  • Kinetic resolution
  • Lewis acid
  • Low valent titanium reagents
  • Olefin methathesis
  • Olefination
  • Regioselectivity
  • Sharpless epoxidation
  • Stereoselectivity
  • Tebbe reagent
  • Titanium enolates

ASJC Scopus subject areas

  • Organic Chemistry

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