Efficient synthetic protocol for substituted guanidines via copper(I)-mediated intermolecular amination of isothiourea derivatives

Hitoshi Ube, Daisuke Uraguchi, Masahiro Terada

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Amination of S-methyl-N,N′-bis-Boc-isothiourea with either primary or sterically hindered secondary amines promoted by copper(I) chloride and K2CO3 gave N,N′-bis-Boc protected guanidines in good to excellent yields under mild reaction conditions.

Original languageEnglish
Pages (from-to)545-549
Number of pages5
JournalJournal of Organometallic Chemistry
Volume692
Issue number1-3
DOIs
Publication statusPublished - 2007 Jan 1

Keywords

  • Amination
  • Copper(I)
  • Guanidine
  • Isothiourea
  • Thiourea

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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