Efficient method for synthesis of angucyclinone antibiotics via gold-catalyzed intramolecular [4 + 2] benzannulation: Enantioselective total synthesis of (+)-ochromycinone and (+)-rubiginone B2

Kenichiro Sato, Naoki Asao, Yoshinori Yamamoto

    Research output: Contribution to journalArticle

    110 Citations (Scopus)

    Abstract

    An efficient synthetic approach to angucyclinone antibiotics, (+)-ochromycinone and (+)-rubiginone B2, is reported. The key step involves the facile formation of 2,3-dihydrophenantren-4(1H)-one skeleton, an important framework of angucyclinone natural products, by using gold-catalyzed intramolecular [4 + 2] benzannulation reaction.

    Original languageEnglish
    Pages (from-to)8977-8981
    Number of pages5
    JournalJournal of Organic Chemistry
    Volume70
    Issue number22
    DOIs
    Publication statusPublished - 2005 Oct 28

    ASJC Scopus subject areas

    • Organic Chemistry

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