Efficient generation of reactive oxygen species sonochemically generated by cavitation bubbles

Jun Yasuda, Shin Yoshizawa, Shinichiro Umemura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Background: Sonodynamic treatment is a cancer treatment method using by cavitation bubbles generated by ultrasound. In sonodynamic treatment, generating ROS efficiently by cavitation bubbles at target cancerous tissue is important. Objective: The aim of this paper is generating ROS efficiently by using exposure sequence which have short, high-intensity ultrasound pulse (triggered pulse) immediate followed by long, moderately low-intensity ultrasound burst (sustaining waves). Experiment: Cavitation bubbles were generated by using two sequences. The firsts sequence had both of triggered pulse and sustaining waves. The second one had only triggered pulse. After ultrasound exposure finished, the amount of ROS was quantified by KI method. Result and conclusion: The sequence which had both trigger pulse and sustaining waves generated ROS more efficient than the sequence which had only triggered pulse. The reason of this result is that sustaining waves oscillated cavitation bubbles volumetrically which were generated by triggered pulse and such volume oscillation of bubbles by sustaining waves contributes for efficient generation of ROS.

Original languageEnglish
Title of host publication2015 IEEE International Ultrasonics Symposium, IUS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479981823
DOIs
Publication statusPublished - 2015 Nov 13
EventIEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China
Duration: 2015 Oct 212015 Oct 24

Publication series

Name2015 IEEE International Ultrasonics Symposium, IUS 2015

Other

OtherIEEE International Ultrasonics Symposium, IUS 2015
CountryTaiwan, Province of China
CityTaipei
Period15/10/2115/10/24

Keywords

  • Cavitation bubbles
  • High-intensity focused ultrasound
  • High-speed observation
  • Sonodynamic treatmement

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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