TY - GEN
T1 - Efficient generation of reactive oxygen species sonochemically generated by cavitation bubbles
AU - Yasuda, Jun
AU - Yoshizawa, Shin
AU - Umemura, Shin Ichiro
N1 - Funding Information:
Acknowledgements This research was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS).
Publisher Copyright:
© 2015 IEEE.
PY - 2015/11/13
Y1 - 2015/11/13
N2 - Background: Sonodynamic treatment is a cancer treatment method using by cavitation bubbles generated by ultrasound. In sonodynamic treatment, generating ROS efficiently by cavitation bubbles at target cancerous tissue is important. Objective: The aim of this paper is generating ROS efficiently by using exposure sequence which have short, high-intensity ultrasound pulse (triggered pulse) immediate followed by long, moderately low-intensity ultrasound burst (sustaining waves). Experiment: Cavitation bubbles were generated by using two sequences. The firsts sequence had both of triggered pulse and sustaining waves. The second one had only triggered pulse. After ultrasound exposure finished, the amount of ROS was quantified by KI method. Result and conclusion: The sequence which had both trigger pulse and sustaining waves generated ROS more efficient than the sequence which had only triggered pulse. The reason of this result is that sustaining waves oscillated cavitation bubbles volumetrically which were generated by triggered pulse and such volume oscillation of bubbles by sustaining waves contributes for efficient generation of ROS.
AB - Background: Sonodynamic treatment is a cancer treatment method using by cavitation bubbles generated by ultrasound. In sonodynamic treatment, generating ROS efficiently by cavitation bubbles at target cancerous tissue is important. Objective: The aim of this paper is generating ROS efficiently by using exposure sequence which have short, high-intensity ultrasound pulse (triggered pulse) immediate followed by long, moderately low-intensity ultrasound burst (sustaining waves). Experiment: Cavitation bubbles were generated by using two sequences. The firsts sequence had both of triggered pulse and sustaining waves. The second one had only triggered pulse. After ultrasound exposure finished, the amount of ROS was quantified by KI method. Result and conclusion: The sequence which had both trigger pulse and sustaining waves generated ROS more efficient than the sequence which had only triggered pulse. The reason of this result is that sustaining waves oscillated cavitation bubbles volumetrically which were generated by triggered pulse and such volume oscillation of bubbles by sustaining waves contributes for efficient generation of ROS.
KW - Cavitation bubbles
KW - High-intensity focused ultrasound
KW - High-speed observation
KW - Sonodynamic treatmement
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U2 - 10.1109/ULTSYM.2015.0402
DO - 10.1109/ULTSYM.2015.0402
M3 - Conference contribution
AN - SCOPUS:84962030110
T3 - 2015 IEEE International Ultrasonics Symposium, IUS 2015
BT - 2015 IEEE International Ultrasonics Symposium, IUS 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - IEEE International Ultrasonics Symposium, IUS 2015
Y2 - 21 October 2015 through 24 October 2015
ER -
