Efficient generation of cavitation bubbles and reactive oxygen species using triggered high-intensity focused ultrasound sequence for sonodynamic treatment

Jun Yasuda, Shin Yoshizawa, Shinichiro Umemura

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Sonodynamic treatment is a method of treating cancer using reactive oxygen species (ROS) generated by cavitation bubbles in collaboration with a sonosensitizer at a target tissue. In this treatment method, both localized ROS generation and ROS generation with high efficiency are important. In this study, a triggered high-intensity focused ultrasound (HIFU) sequence, which consists of a short, extremely high intensity pulse immediately followed by a long, moderate-intensity burst, was employed for the efficient generation of ROS. In experiments, a solution sealed in a chamber was exposed to a triggered HIFU sequence. Then, the distribution of generated ROS was observed by the luminol reaction, and the amount of generated ROS was quantified using KI method. As a result, the localized ROS generation was demonstrated by light emission from the luminol reaction. Moreover, it was demonstrated that the triggered HIFU sequence has higher efficiency of ROS generation by both the KI method and the luminol reaction emission.

Original languageEnglish
Article number07KF24
JournalJapanese journal of applied physics
Volume55
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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