Efficient formation of luminescent lanthanide(III) complexes by solid-phase synthesis and on-resin screening

Tatsuya Nakamura, Shin Mizukami, Miho Tanaka, Kazuya Kikuchi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Time-resolved luminescence measurements of luminescent lanthanide complexes have advantages in biological assays and high-throughput screening, owing to their high sensitivity. In spite of the recent advances in their energy-transfer mechanism and molecular-orbital-based computational molecular design, it is still difficult to estimate the quantum yields of new luminescent lanthanide complexes. Herein, solid-phase libraries of luminescent lanthanide complexes were prepared through amide-condensation and Pd-catalyzed coupling reactions and their luminescent properties were screened with a microplate reader. Good correlation was observed between the time-resolved luminescence intensities of the solid-phase libraries and those of the corresponding complexes that were synthesized by using liquid-phase chemistry. This method enabled the rapid and efficient development of new sensitizers for SmIII, EuIII, and TbIII luminescence. Thus, solid-phase combinatorial synthesis combined with on-resin screening led to the discovery of a wide variety of luminescent sensitizers. La confidential: Solid-phase synthesis by using amide-condensation and Pd-coupling reactions enabled the efficient development of new antenna ligands for SmIII, EuIII, and Tb III atoms for discovering a wide variety of luminescent sensitizers.

Original languageEnglish
Pages (from-to)2685-2690
Number of pages6
JournalChemistry - An Asian Journal
Volume8
Issue number11
DOIs
Publication statusPublished - 2013 Nov
Externally publishedYes

Keywords

  • lanthanides
  • ligand effects
  • luminescence
  • sensitizers
  • solid-phase synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Efficient formation of luminescent lanthanide(III) complexes by solid-phase synthesis and on-resin screening'. Together they form a unique fingerprint.

Cite this