Abstract
A model compound (6) with the core skeleton of lysidicin A was synthesized as a racemate. The key step (8→7) includes three Claisen rearrangements of the triether with phloroglucinols; two of which rearranged in a cascade manner and the other was a simple rearrangement. This one-pot reaction enabled the introduction of three phloroglucinol units at the correct positions and makes the synthetic approach significantly efficient.
Original language | English |
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Pages (from-to) | 3294-3296 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 25 |
DOIs | |
Publication status | Published - 2010 Jun 23 |
Externally published | Yes |
Keywords
- Cascade reaction
- Claisen rearrangement
- Lysidicin A
- Vasodilation activity
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry