Efficient asymmetric α-oxyamination of aldehydes by resin-supported peptide catalyst in aqueous media

Kengo Akagawa, Takuma Fujiwara, Seiji Sakamoto, Kazuaki Kudo

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

The resin-supported peptide catalyst having the terminal five-residue Pro-d-Pro-Aib-Trp-Trp combined with polyleucine successfully catalyzed the asymmetric α-oxyamination of aldehydes in aqueous media. The secondary structure and the chirality sense of the hydrophobic polyleucine chain significantly affected both reactivity and enantioselectivity.

Original languageEnglish
Pages (from-to)1804-1807
Number of pages4
JournalOrganic letters
Volume12
Issue number8
DOIs
Publication statusPublished - 2010 Apr 16

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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