Abstract
Simple synthesis of (±)-estrone methyl ether by the conjugate addition-enolate methylation of the 2-alkylcyclopentenone followed by the intramolecular Diels-Alder reaction of the o-quinodimethane, and discussions for the diastereoselectivity in the enolatemethylation based on the MM2 transition structure model are presented.
Original language | English |
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Pages (from-to) | 4999-5002 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 30 |
Issue number | 37 |
DOIs | |
Publication status | Published - 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry