Efficient and substrate-specific hydration of nitriles to amides in water by using a CeO2 catalyst

Masazumi Tamura, Hiroko Wakasugi, Ken Ichi Shimizu, Atsushi Satsuma

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

CeO2 acted as a reusable and effective catalyst for the hydration of various nitriles to amides in water under neutral conditions at low temperature (30-100 °C). CeO2 showed notable substrate specificity for nitriles that have a heteroatom adjacent to the α-carbon atom of the CN group (see scheme).

Original languageEnglish
Pages (from-to)11428-11431
Number of pages4
JournalChemistry - A European Journal
Volume17
Issue number41
DOIs
Publication statusPublished - 2011 Oct 4
Externally publishedYes

Keywords

  • amides
  • cerium
  • hydration
  • nitriles
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

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