Efficient and improved synthesis of triazole-linked DNA ( TLDNA) oligomers

Tomoko Fujino; Naomi Yamazaki; Ai Hasome; Kenta Endo; Hiroyuki Isobe

doi:10.1016/j.tetlet.2011.12.026

Efficient and improved synthesis of triazole-linked DNA ( ^TLDNA) oligomers

Tomoko Fujino, Naomi Yamazaki, Ai Hasome, Kenta Endo, Hiroyuki Isobe

SCI - Chemistry

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

A method for the synthesis of triazole-linked DNA oligomers has been revisited to incorporate a reliable protective group and linker for solid-phase synthesis. The new solid-phase synthesis allowed the preparation of oligomers with the efficiency of elongation reaching over 90%.

Original language	English
Pages (from-to)	868-870
Number of pages	3
Journal	Tetrahedron Letters
Volume	53
Issue number	7
DOIs	https://doi.org/10.1016/j.tetlet.2011.12.026
Publication status	Published - 2012 Feb 15

Keywords

DNA
Oligonucleotides
Protection
Solid-phase synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Fujino, T., Yamazaki, N., Hasome, A., Endo, K., & Isobe, H. (2012). Efficient and improved synthesis of triazole-linked DNA ( ^TLDNA) oligomers. Tetrahedron Letters, 53(7), 868-870. https://doi.org/10.1016/j.tetlet.2011.12.026

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AU - Hasome, Ai

AU - Endo, Kenta

AU - Isobe, Hiroyuki

PY - 2012/2/15

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KW - Protection

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