Efficient and improved synthesis of triazole-linked DNA ( TLDNA) oligomers

Tomoko Fujino; Naomi Yamazaki; Ai Hasome; Kenta Endo; Hiroyuki Isobe

doi:10.1016/j.tetlet.2011.12.026

Efficient and improved synthesis of triazole-linked DNA ( ^TLDNA) oligomers

Tomoko Fujino, Naomi Yamazaki, Ai Hasome, Kenta Endo, Hiroyuki Isobe

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A method for the synthesis of triazole-linked DNA oligomers has been revisited to incorporate a reliable protective group and linker for solid-phase synthesis. The new solid-phase synthesis allowed the preparation of oligomers with the efficiency of elongation reaching over 90%.

Original language	English
Pages (from-to)	868-870
Number of pages	3
Journal	Tetrahedron Letters
Volume	53
Issue number	7
DOIs	https://doi.org/10.1016/j.tetlet.2011.12.026
Publication status	Published - 2012 Feb 15
Externally published	Yes

Keywords

DNA
Oligonucleotides
Protection
Solid-phase synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2011.12.026

Cite this

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title = "Efficient and improved synthesis of triazole-linked DNA ( TLDNA) oligomers",

abstract = "A method for the synthesis of triazole-linked DNA oligomers has been revisited to incorporate a reliable protective group and linker for solid-phase synthesis. The new solid-phase synthesis allowed the preparation of oligomers with the efficiency of elongation reaching over 90%.",

keywords = "DNA, Oligonucleotides, Protection, Solid-phase synthesis",

author = "Tomoko Fujino and Naomi Yamazaki and Ai Hasome and Kenta Endo and Hiroyuki Isobe",

note = "Funding Information: This study is partly supported by KAKENHI (20108015, 23550041), the Takeda Science Foundation and the Banyu Life Science Foundation. We thank the Asahi Techno Glass Co. for the generous relief supply of glassware after the Tohoku earthquake. A preliminary contribution of Y. Suzuki is gratefully acknowledged. N.Y. thanks JSPS for the predoctoral fellowship. ",

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T1 - Efficient and improved synthesis of triazole-linked DNA ( TLDNA) oligomers

AU - Fujino, Tomoko

AU - Yamazaki, Naomi

AU - Hasome, Ai

AU - Endo, Kenta

AU - Isobe, Hiroyuki

N1 - Funding Information: This study is partly supported by KAKENHI (20108015, 23550041), the Takeda Science Foundation and the Banyu Life Science Foundation. We thank the Asahi Techno Glass Co. for the generous relief supply of glassware after the Tohoku earthquake. A preliminary contribution of Y. Suzuki is gratefully acknowledged. N.Y. thanks JSPS for the predoctoral fellowship.

PY - 2012/2/15

Y1 - 2012/2/15

N2 - A method for the synthesis of triazole-linked DNA oligomers has been revisited to incorporate a reliable protective group and linker for solid-phase synthesis. The new solid-phase synthesis allowed the preparation of oligomers with the efficiency of elongation reaching over 90%.

AB - A method for the synthesis of triazole-linked DNA oligomers has been revisited to incorporate a reliable protective group and linker for solid-phase synthesis. The new solid-phase synthesis allowed the preparation of oligomers with the efficiency of elongation reaching over 90%.

KW - DNA

KW - Oligonucleotides

KW - Protection

KW - Solid-phase synthesis

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

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