Efficient and improved synthesis of triazole-linked DNA ( TLDNA) oligomers

Tomoko Fujino, Naomi Yamazaki, Ai Hasome, Kenta Endo, Hiroyuki Isobe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A method for the synthesis of triazole-linked DNA oligomers has been revisited to incorporate a reliable protective group and linker for solid-phase synthesis. The new solid-phase synthesis allowed the preparation of oligomers with the efficiency of elongation reaching over 90%.

Original languageEnglish
Pages (from-to)868-870
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number7
DOIs
Publication statusPublished - 2012 Feb 15

Keywords

  • DNA
  • Oligonucleotides
  • Protection
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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