Efficient diastereoselective alkylation of 6- and £-keto acids with Grignard reagents was achieved in up to 97% de by conversion into the : 2′-[3-(2-methoxyethoxy)propoxy]-(1,1′-binaphthyl)-2-ol esters, while the corresponding alkylation of ζ- to θ-keto acids could effectively be carried out in up to 88% de by simply using BINOL as the chiral auxiliary.
|Number of pages||2|
|Journal||Journal of the Chemical Society - Perkin Transactions 1|
|Publication status||Published - 1999 Dec 1|
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