TY - JOUR
T1 - Efficacy of tiotropium/olodaterol on lung volume, exercise capacity, and physical activity
AU - Ichinose, Masakazu
AU - Minakata, Yoshiaki
AU - Motegi, Takashi
AU - Ueki, Jun
AU - Gon, Yasuhiro
AU - Seki, Tetsuo
AU - Anzai, Tatsuhiko
AU - Nakamura, Shuhei
AU - Hirata, Kazuto
N1 - Funding Information:
We thank all the patients involved in this study. We also thank the following investigators for their assistance in conducting this study: Osamu Hataji, Matsusaka City Hospital, Matsusaka, Mie, Japan; Yuji Higashimoto, Kindai University Hospital, Osakasayama, Osaka, Japan; Yasuhiro Kondoh, Tosei General Hospital, Seto, Aichi, Japan; Masaru Suzuki, Hokkaido University Hospital, Sapporo, Hokkaido, Japan; Hiroyuki Ohbayashi, Tohno Chuo Clinic, Mizunami, Gifu, Japan; Takefumi Saito, NHO Ibarakihigashi National Hospital, Naka-gun, Ibaraki, Japan; Kazuhisa Asai, Osaka City University Hospital, Osaka, Japan; Motohiko Miura, Japan Organization of Occupational Health and Safety Tohoku Rosai Hospital, Sendai, Miyagi, Japan; Naoki Miyao, Medical Corporation Kokankai Kokan Clinic, Kawasaki, Kanagawa, Japan; Hirotaka Nagashima, Shinjuku Research Park Clinic, Shinjuku-ku, Tokyo, Japan; Hisatoshi Sugiura, Tohoku University Hospital, Sendai, Miyagi, Japan; Toshiyuki Harada, Japan Community Health Care Organization Hokkaido Hospital, Sapporo, Hokkaido, Japan; Tetsuo Hiramatsu, Hiramatsu Internal and Respiratory Medicine Clinic, Komaki, Aichi, Japan; Michiko Tsuchiya, Raku-wakai Otowa Hospital, Kyoto, Japan; Takashi Kinoshita, Kurume University Hospital, Kurume, Fukuoka, Japan; Tohru Tsuda, Kirigaoka Tsuda Hospital, Kitakyushu, Fukuoka, Japan; Shigeo Muro, Kyoto University Hospital, Kyoto, Japan; Yu Utsumi, Iwate Medical University Hospital, Morioka, Iwate, Japan; Toshio Ichiwata, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo, Japan; Masahiro Kaneko, Kobe City Hospital Organization Kobe City Medical Center West Hospital, Kobe, Hyogo, Japan; Takuya Samukawa, Kagoshima University Hospital and Dental Hospital, Kagoshima, Japan; Takashi Motegi, Respiratory Care Clinic, Nippon Medical School, Chiyoda-ku, Tokyo, Japan; Yoshiaki Minakata, NHO Wakayama Hospital, Hidaka-gun, Wakayama, Japan; Satoshi Fuke, KKR Sapporo Medical Center, Sapporo, Hokkaido, Japan; Motokazu Kato, Kishiwada City Hospital, Kishiwada, Osaka, Japan; Yasuhiro Gon, Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, Japan; Atsushi Nagai, Shin-yurigaoka General Hospital, Kawasaki, Kanagawa, Japan; Hiromasa Harada, Yao Tokushukai General Hospital, Yao, Osaka, Japan; Keisuke Tomii, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan; Yasuko Harada, Nishi Fukuoka Hospital, Fukuoka, Japan; Masahiko Saito, Uji Tokushukai Medical Center, Uji, Kyoto, Japan; Tadashi Sato, Juntendo University Hospital, Bunkyo-ku, Tokyo, Japan; Hironori Sagara, Showa University Hospital, Shinagawa-ku, Tokyo, Japan; Hiroyuki Nakamura, Sakaide City Hospital, Sakaide, Kagawa, Japan; Yusuke Shikama, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan; Shinichi Osaki, Osaki Internal and Respiratory Clinic, Kitakyushu, Fukuoka, Japan; Koichi Nishimura, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; Hiroyuki Koba, Teine Keijinkai Clinic, Sapporo, Hokkaido, Japan; Keisuke Miki, NHO Toneyama National Hospital, Toyonaka, Osaka, Japan; Yuriko Mizobe, Nihonbashi Sakura Clinic, Chuo-ku, Tokyo, Japan; Yojiro Onari, Mazda Hospital, Aki-gun, Hiroshima, Japan; Hiroshi Hayakawa, NHO Tenryu Hospital, Hamamatsu, Shizuoka, Japan; Tetsuji Kawamura, NHO Himeji Medical Center, Himeji, Hyogo, Japan; Takeshi Isobe, Shimane University Hospital, Izumo, Shimane, Japan. Medical writing assistance was provided by Allison Kirsop, PhD, and Marion Barnett of Edanz Medical Writing, with publication management and editorial support by Daisuke Kuroki of Nippon Boehringer Ingelheim. This study was funded by Nippon Boehringer Ingelheim Co., Ltd. Nippon Boehringer Ingelheim contributed to the design of the study, data collection, analysis, and interpretation of the study results. Nippon Boehringer Ingelheim also funded the medical writing support, publication charges, and open access fee for publication of this manuscript.
Publisher Copyright:
© 2018 Ichinose et al.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Purpose: This study evaluated the efficacy of tiotropium/olodaterol vs tiotropium on lung function, exercise capacity, and physical activity in patients with COPD. Patients and methods: A total of 184 patients aged ≥40 years with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II–IV) received tiotropium/olodaterol for 6 weeks, then tiotropium for 6 weeks, or vice versa. The primary endpoint was inspiratory capacity (IC) at peak post-dose. Results: Adjusted mean IC after 6-week treatment was 1.990 L with tiotropium/olodaterol vs 1.875 L with tiotropium (difference: 115 mL; 95% CI: 77, 153; p<0.0001). Forced expiratory volume in 1 s (difference: 105 mL; 95% CI: 88, 123), forced vital capacity (difference: 163 mL; 95% CI: 130, 197), and slow vital capacity (difference: 134 mL; 95% CI: 91, 176) improved with tiotropium/olodaterol (all p<0.0001). Adjusted mean 6-min walk distance was similar between treatments in the overall population but was significantly increased with tiotropium/olodaterol in the subgroup with Global Initiative for Chronic Obstructive Lung Disease stage III/IV at baseline (difference: 18.1 m; 95% CI: 2.3, 33.9; p=0.0254). In a post hoc analysis, tiotropium/olodaterol improved the values for ≥2.0 metabolic equivalents (difference: 5.0 min; 95% CI: 0.4, 9.7; p=0.0337). Conclusion: Tiotropium/olodaterol significantly improved IC compared with tiotropium and potentially enhanced the exercise capacity in COPD patients. A slight improvement in physical activity of relatively more than moderate intensity was also seen with tiotropium/olodaterol.
AB - Purpose: This study evaluated the efficacy of tiotropium/olodaterol vs tiotropium on lung function, exercise capacity, and physical activity in patients with COPD. Patients and methods: A total of 184 patients aged ≥40 years with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II–IV) received tiotropium/olodaterol for 6 weeks, then tiotropium for 6 weeks, or vice versa. The primary endpoint was inspiratory capacity (IC) at peak post-dose. Results: Adjusted mean IC after 6-week treatment was 1.990 L with tiotropium/olodaterol vs 1.875 L with tiotropium (difference: 115 mL; 95% CI: 77, 153; p<0.0001). Forced expiratory volume in 1 s (difference: 105 mL; 95% CI: 88, 123), forced vital capacity (difference: 163 mL; 95% CI: 130, 197), and slow vital capacity (difference: 134 mL; 95% CI: 91, 176) improved with tiotropium/olodaterol (all p<0.0001). Adjusted mean 6-min walk distance was similar between treatments in the overall population but was significantly increased with tiotropium/olodaterol in the subgroup with Global Initiative for Chronic Obstructive Lung Disease stage III/IV at baseline (difference: 18.1 m; 95% CI: 2.3, 33.9; p=0.0254). In a post hoc analysis, tiotropium/olodaterol improved the values for ≥2.0 metabolic equivalents (difference: 5.0 min; 95% CI: 0.4, 9.7; p=0.0337). Conclusion: Tiotropium/olodaterol significantly improved IC compared with tiotropium and potentially enhanced the exercise capacity in COPD patients. A slight improvement in physical activity of relatively more than moderate intensity was also seen with tiotropium/olodaterol.
KW - COPD
KW - FEV
KW - FVC
KW - Inspiratory capacity
KW - Japanese
UR - http://www.scopus.com/inward/record.url?scp=85047065688&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047065688&partnerID=8YFLogxK
U2 - 10.2147/COPD.S166023
DO - 10.2147/COPD.S166023
M3 - Article
C2 - 29750027
AN - SCOPUS:85047065688
VL - 13
SP - 1407
EP - 1419
JO - International Journal of COPD
JF - International Journal of COPD
SN - 1176-9106
ER -
