TY - JOUR
T1 - Efficacy of sumatriptan in two pediatric cases with abdominal pain-related functional gastrointestinal disorders
T2 - Does the mechanism overlap that of migraine?
AU - Kakisaka, Yosuke
AU - Wakusawa, Keisuke
AU - Haginoya, Kazuhiro
AU - Saito, Akiko
AU - Uematsu, Mitsugu
AU - Yokoyama, Hiroyuki
AU - Sato, Tetsuo
AU - Tsuchiya, Shigeru
PY - 2010/2
Y1 - 2010/2
N2 - We successfully treated 2 pediatric cases of abdominal pain-related functional gastrointestinal disorder with sumatriptan. When 9 years old, patient 1 developed periodic abdominal pain that was intractable to medication and remitted spontaneously. She was diagnosed with abdominal migraine, categorized as H2c in the Rome III criteria for functional gastrointestinal disorders. At age 12, intranasal sumatriptan relieved her pain, and her attacks halted 2 years later. Patient 2 was a 9-year-old girl diagnosed with attention-deficit hyperactivity disorder (ADHD), who began to have intermittent abdominal pain of variable severity, which sometimes restricted daily activity. She was diagnosed with childhood functional abdominal pain syndrome, categorized as H2d1 using the Rome III criteria. Intranasal sumatriptan also relieved her pain. These cases suggest that the mechanism of pain in abdominal pain-related functional gastrointestinal disorders is similar to that of migraine, with probable central hypersensitivity, at least in a subset of cases.
AB - We successfully treated 2 pediatric cases of abdominal pain-related functional gastrointestinal disorder with sumatriptan. When 9 years old, patient 1 developed periodic abdominal pain that was intractable to medication and remitted spontaneously. She was diagnosed with abdominal migraine, categorized as H2c in the Rome III criteria for functional gastrointestinal disorders. At age 12, intranasal sumatriptan relieved her pain, and her attacks halted 2 years later. Patient 2 was a 9-year-old girl diagnosed with attention-deficit hyperactivity disorder (ADHD), who began to have intermittent abdominal pain of variable severity, which sometimes restricted daily activity. She was diagnosed with childhood functional abdominal pain syndrome, categorized as H2d1 using the Rome III criteria. Intranasal sumatriptan also relieved her pain. These cases suggest that the mechanism of pain in abdominal pain-related functional gastrointestinal disorders is similar to that of migraine, with probable central hypersensitivity, at least in a subset of cases.
KW - Abdominal migraine
KW - Childhood functional abdominal pain syndromes
KW - Sumatriptan
UR - http://www.scopus.com/inward/record.url?scp=76049107391&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=76049107391&partnerID=8YFLogxK
U2 - 10.1177/0883073809336875
DO - 10.1177/0883073809336875
M3 - Article
C2 - 19509407
AN - SCOPUS:76049107391
VL - 25
SP - 234
EP - 237
JO - Journal of Child Neurology
JF - Journal of Child Neurology
SN - 0883-0738
IS - 2
ER -