Efficacy of roxithromycin in the treatment of mycoplasma pneumonia

Mitsuo Kaku, Shigeru Kohno, Hironobu Koga, Kazuo Ishida, Kohei Hara

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Macrolide and tetracycline antibiotics, which are protein syn-thesis inhibitors, are effective in the treatment of mycoplasma pneumonia. We evaluated the clinical efficacy and safety of roxithromycin, a new macrolide antibiotic, in the treatment of mycoplasma pneumonia. Roxithromycin was administered orally to patients who had been definitely diagnosed through Mycoplasma pneumoniae isolation or serum antibody titer as having mycoplasma pneumonia. The efficacy assessment was based on clinical signs and symptoms of infection as well as bacterial culture from clinical samples. Clinical efficacy was ex-cellent in 6 cases, good in 6 cases and fair in 1 case, with an efficacy rate of 92.3%. The bacteriological effect was evaluated in 6 patients: The organism was eradicated in 4 cases and unchanged in 2 cases. In this study, the MIC of roxithromycin against M. pneumoniae fell in the range 0.0156-0.00625 mg/1. No adverse reaction was observed. As for abnormal laboratory findings, two cases showed elevated serum glutamic-pyruvic transaminase (S-GPT), one elevated serum glutamic-oxaloacetic transaminase and S-GPT, and one reduced neutrophil counts. From our results, we consider that roxithromycin is useful in the treatment of mycoplasma pneumonia.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalChemotherapy
Volume41
Issue number2
DOIs
Publication statusPublished - 1995 Jan 1

Keywords

  • Mycoplasma pneumonia
  • Roxithromycin

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

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