Efficacy of neoadjuvant chemotherapy followed by radical hysterectomy in locally advanced non-squamous carcinoma of the uterine cervix: A retrospective multicenter study of Tohoku Gynecologic Cancer Unit

T. Shoji, S. Kumagai, A. Yoshizaki, Y. Yokoyama, T. Fujimoto, T. Takano, N. Yaegashi, K. Nakahara, H. Nishiyama, T. Sugiyama

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9 Citations (Scopus)

Abstract

Objective: Radical hysterectomy (RH) is a standard treatment for locally advanced non-squamous cell carcinoma (N-SCC) of the uterine cervix, but there have been no reports on whether neoadjuvant chemotherapy (NAC) followed by radical hysterectomy could improve the outcome of patients with this disease. Materials and Methods: This multicenter retrospective study enrolled 77 patients with Stage IB2 to HB N-SCC of the uterine cervix. Of these, 27 patients were treated with NAC prior to radical hysterectomy (NAC group) and 50 with RH alone (RH group). The two-year recurrence-free survival (RFS) rate, progression-free survival (PFS), and overall survival (OS) were compared between the two groups. Clinical parameters such as clinical stage, histological type, and post-operative treatment were also examined between the groups. Results: While the two-year RFS rates were 81.5% and 70.0% in NAC and RH groups, respectively (p = 0.27) and the median PFS was 51 months and 35 months in NAC and RH groups, respectively (p = 0.35), the median OS was 58 months and 48 months in NAC and RH groups, respectively, which was significant (p = 0.0014). The median OS of patients with mucinous adenocarcinoma in NAC group was significantly higher than that in RH group: 58 months versus 37 months (p = 0.03). Conclusion: NAC prior to RH may offer the prognostic advantage of patients with locally advanced N-SCC of the uterine cervix, especially mucinous adenocarcinoma.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalEuropean Journal of Gynaecological Oncology
Volume33
Issue number4
Publication statusPublished - 2012 Sep 17

Keywords

  • Neoadjuvant chemotherapy
  • Non-squamous cell carcinoma
  • Outcome
  • Radical hysterectomy
  • Uterine cervical carcinoma

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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