Efficacy of idebenone for respiratory failure in a patient with Leigh syndrome: A long-term follow-up study

Kazuhiro Haginoya, Shigeaki Miyabayashi, Masahiro Kikuchi, Akira Kojima, Katsuya Yamamoto, Kiyoshi Omura, Mitsugu Uematsu, Naomi Fukuyo, Soichiro Tanaka, Shigeru Tsuchiya

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23 Citations (Scopus)

Abstract

Respiratory failure can be the direct cause of death in patients with Leigh syndrome. Unfortunately, no effective treatment strategy is available. Here, we report successful treatment of a patient with Leigh syndrome using idebenone, a derivative of coenzyme Q-10. The patient's brainstem function, especially respiratory function, improved after idebenone treatment. Idebenone may be worth trying in patients with Leigh syndrome.

Original languageEnglish
Pages (from-to)112-114
Number of pages3
JournalJournal of the neurological sciences
Volume278
Issue number1-2
DOIs
Publication statusPublished - 2009 Mar 15

Keywords

  • Idebenone
  • Leigh syndrome
  • Mitochondrial encephalopathy
  • Respiratory failure

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Haginoya, K., Miyabayashi, S., Kikuchi, M., Kojima, A., Yamamoto, K., Omura, K., Uematsu, M., Fukuyo, N., Tanaka, S., & Tsuchiya, S. (2009). Efficacy of idebenone for respiratory failure in a patient with Leigh syndrome: A long-term follow-up study. Journal of the neurological sciences, 278(1-2), 112-114. https://doi.org/10.1016/j.jns.2008.11.008