Efficacy of glucose infusion for the inhibition of breakdown of fat tissue and muscle protein under remifentanil anesthesia

Atsushi Sawada, Yusuke Yoshikawa, Masanori Yamauchi, Akihiko Watanabe, Michiaki Yamakage

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background : We investigated the efficacy of glucose infusion for the inhibition of breakdown of fat tissue and muscle protein under remifentanil anesthesia. Methods : Twenty adult patients (ASA I or II) were enrolled in this study and randomized into two groups : a control group receiving acetated Ringer's solution without glucose (n=10) and a glucose group receiving acetated Ringer's solution containing 1% glucose (n=10). Anesthesia was induced by propofol and fentanyl and maintained by sevoflurane and remifentanil. Plasma concentrations of glucose and cortisol were measured. Acetoacetic acid and 3-hydroxybutyrate acid were measured as parameters for breakdown of fat tissue. Urine 3-methylhistidine/plasma creatinine was measured as a parameter for breakdown of muscle protein during surgery. Data were analyzed by the unpaired t-test, Friedman's chi 2-test, Wilcoxon's t-test and Mann-Whitney U test. P < 0.05 was considered significant. Results : Plasma concentrations of Cortisol and glucose were not increased in either group during the study. Plasma concentrations of acetoacetic acid and 3-hydroxybutyrate acid and urine 3-methylhistidine/plasma creatinine significantly increased in the control group but did not increase in the glucose group. Conclusions : Infusion of glucose suppresses breakdown of fat tissue and muscle protein under remifentanil anesthesia.

Original languageEnglish
Pages (from-to)358-363
Number of pages6
JournalJapanese Journal of Anesthesiology
Volume61
Issue number4
Publication statusPublished - 2012 Apr 10
Externally publishedYes

Keywords

  • Acetated Ringer's solution containing 1% glucose
  • Breakdown of fat tissue
  • Breakdown of muscle protein
  • Remifentanil

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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