Abstract
Background : We investigated the efficacy of glucose infusion for the inhibition of breakdown of fat tissue and muscle protein under remifentanil anesthesia. Methods : Twenty adult patients (ASA I or II) were enrolled in this study and randomized into two groups : a control group receiving acetated Ringer's solution without glucose (n=10) and a glucose group receiving acetated Ringer's solution containing 1% glucose (n=10). Anesthesia was induced by propofol and fentanyl and maintained by sevoflurane and remifentanil. Plasma concentrations of glucose and cortisol were measured. Acetoacetic acid and 3-hydroxybutyrate acid were measured as parameters for breakdown of fat tissue. Urine 3-methylhistidine/plasma creatinine was measured as a parameter for breakdown of muscle protein during surgery. Data were analyzed by the unpaired t-test, Friedman's chi 2-test, Wilcoxon's t-test and Mann-Whitney U test. P < 0.05 was considered significant. Results : Plasma concentrations of Cortisol and glucose were not increased in either group during the study. Plasma concentrations of acetoacetic acid and 3-hydroxybutyrate acid and urine 3-methylhistidine/plasma creatinine significantly increased in the control group but did not increase in the glucose group. Conclusions : Infusion of glucose suppresses breakdown of fat tissue and muscle protein under remifentanil anesthesia.
Original language | English |
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Pages (from-to) | 358-363 |
Number of pages | 6 |
Journal | Japanese Journal of Anesthesiology |
Volume | 61 |
Issue number | 4 |
Publication status | Published - 2012 Apr 10 |
Externally published | Yes |
Keywords
- Acetated Ringer's solution containing 1% glucose
- Breakdown of fat tissue
- Breakdown of muscle protein
- Remifentanil
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine