Efficacy of early piston-type high-frequency oscillatory ventilation in infants with respiratory distress syndrome

Takeo Sakai, Takasi Kamohara, Satoru Aiba, Tosiro Yoshioka, Akiko Itinohe, Hiroo Chiba, Tatsuya Watanabe, Kazuie Iinuma

    Research output: Contribution to journalArticlepeer-review


    We investigated whether the combination of surfactant replacement therapy and early application of high-frequency oscillatory ventilation (HFOV) was more effective in patients with respiratory distress syndrome (RDS) than late application of HFOV and conventional mechanical ventilation (CMV). To determine this, we retrospectively reviewed the cases of 126 neonates with RDS who received surfactant replacement therapy within 4 hr after birth. Patients were grouped into those who received HFOV immediately after birth (HFOV group), those who initially were ventilated by CMV and subsequently received HFOV (CMV/HFOV group), and those who did not receive HFOV (CMV group). Changes in respiratory system compliance (Crs), arterial-alveolar oxygen gradient (a/ApO2), and mean airway pressure (MAP) were compared. Infants who received HFOV were Jess mature than those who received CMV. The a/ApO2 measured immediately after birth before surfactant replacement therapy was significantly lower in the HFOV and CMV/HFOV group than in the CMV group. After 72 hr, the Crs in the HFOV group was higher than in any other group and was significantly higher than the CMV/HFOV group at 48 and 120 hr. These results suggest that initiating HFOV in combination with surfactant replacement therapy immediately after birth provides effective ventilatory support for infants with RDS.

    Original languageEnglish
    Pages (from-to)168-174
    Number of pages7
    JournalPediatric Pulmonology
    Issue number2
    Publication statusPublished - 2001


    • High-frequency oscillatory ventilation
    • Pulmonary function
    • Respiratory distress syndrome
    • Surfactant replacement therapy
    • Very low birth weight infant

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Pulmonary and Respiratory Medicine


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