Efficacy of continuous acyclovir infusion in neonatal herpes virus encephalitis

Y. Kakisaka, M. Ishitobi, K. Wakusawa, K. Haginoya, N. Togashi, T. Kitamura, N. Hino-Fukuyo, I. Sato, M. Uematsu, S. Tsuchiya

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We have successfully eliminated herpes simplex virus-2 from the central nervous system in a case of neonatal herpes simplex virus encephalitis with a continuous acyclovir infusion. A male infant delivered from a healthy 22-year-old woman without genital or systemic herpes symptoms around delivery began to develop fever and intractable seizures. He was started on intermittent intravenous acyclovir (20mg/kg every 8h) based on the diagnosis of herpes encephalitis. The virus was not eliminated with intermittent acyclovir and vidarabine, while continuous acyclovir was ultimately effective in eliminating herpes simplex virus from his central nervous system. This report demonstrates the efficacy of continuous acyclovir infusion in neonatal herpes simplex virus encephalitis.

Original languageEnglish
Pages (from-to)199-200
Number of pages2
JournalNeuropediatrics
Volume40
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • continuous acyclovir infusion
  • herpes simplex virus-2
  • neonatal herpes encephalitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Efficacy of continuous acyclovir infusion in neonatal herpes virus encephalitis'. Together they form a unique fingerprint.

Cite this