TY - JOUR
T1 - Effects of triazole derivatives on strigolactone levels and growth retardation in rice
AU - Ito, Shinsaku
AU - Umehara, Mikihisa
AU - Hanada, Atsushi
AU - Kitahata, Nobutaka
AU - Hayase, Hiroki
AU - Yamaguchi, Shinjiro
AU - Asami, Tadao
PY - 2011
Y1 - 2011
N2 - We previously discovered a lead compound for strigolactone (SL) biosynthesis inhibitors, TIS13 (2,2-dimethyl-7-phenoxy-4-(1H-1,2,4-triazol-1-yl)heptan-3-ol). Here, we carried out a structure-activity relationship study of TIS13 to discover more potent and specific SL biosynthesis inhibitor because TIS13 has a severe side effect at high concentrations, including retardation of the growth of rice seedlings. TIS108, a new TIS13 derivative, was found to be a more specific SL biosynthesis inhibitor than TIS13. Treatment of rice seedlings with TIS108 reduced SL levels in both roots and root exudates in a concentration-dependent manner and did not reduce plant height. In addition, root exudates of TIS108-treated rice seedlings stimulated Striga germination less than those of control plants. These results suggest that TIS108 has a potential to be applied in the control of root parasitic weeds germination.
AB - We previously discovered a lead compound for strigolactone (SL) biosynthesis inhibitors, TIS13 (2,2-dimethyl-7-phenoxy-4-(1H-1,2,4-triazol-1-yl)heptan-3-ol). Here, we carried out a structure-activity relationship study of TIS13 to discover more potent and specific SL biosynthesis inhibitor because TIS13 has a severe side effect at high concentrations, including retardation of the growth of rice seedlings. TIS108, a new TIS13 derivative, was found to be a more specific SL biosynthesis inhibitor than TIS13. Treatment of rice seedlings with TIS108 reduced SL levels in both roots and root exudates in a concentration-dependent manner and did not reduce plant height. In addition, root exudates of TIS108-treated rice seedlings stimulated Striga germination less than those of control plants. These results suggest that TIS108 has a potential to be applied in the control of root parasitic weeds germination.
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U2 - 10.1371/journal.pone.0021723
DO - 10.1371/journal.pone.0021723
M3 - Article
C2 - 21760901
AN - SCOPUS:79960098461
VL - 6
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 7
M1 - e21723
ER -