Effects of triazole derivatives on strigolactone levels and growth retardation in rice

Shinsaku Ito; Mikihisa Umehara; Atsushi Hanada; Nobutaka Kitahata; Hiroki Hayase; Shinjiro Yamaguchi; Tadao Asami

doi:10.1371/journal.pone.0021723

Effects of triazole derivatives on strigolactone levels and growth retardation in rice

Shinsaku Ito, Mikihisa Umehara, Atsushi Hanada, Nobutaka Kitahata, Hiroki Hayase, Shinjiro Yamaguchi, Tadao Asami

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We previously discovered a lead compound for strigolactone (SL) biosynthesis inhibitors, TIS13 (2,2-dimethyl-7-phenoxy-4-(1H-1,2,4-triazol-1-yl)heptan-3-ol). Here, we carried out a structure-activity relationship study of TIS13 to discover more potent and specific SL biosynthesis inhibitor because TIS13 has a severe side effect at high concentrations, including retardation of the growth of rice seedlings. TIS108, a new TIS13 derivative, was found to be a more specific SL biosynthesis inhibitor than TIS13. Treatment of rice seedlings with TIS108 reduced SL levels in both roots and root exudates in a concentration-dependent manner and did not reduce plant height. In addition, root exudates of TIS108-treated rice seedlings stimulated Striga germination less than those of control plants. These results suggest that TIS108 has a potential to be applied in the control of root parasitic weeds germination.

Original language	English
Article number	e21723
Journal	PloS one
Volume	6
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0021723
Publication status	Published - 2011

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

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abstract = "We previously discovered a lead compound for strigolactone (SL) biosynthesis inhibitors, TIS13 (2,2-dimethyl-7-phenoxy-4-(1H-1,2,4-triazol-1-yl)heptan-3-ol). Here, we carried out a structure-activity relationship study of TIS13 to discover more potent and specific SL biosynthesis inhibitor because TIS13 has a severe side effect at high concentrations, including retardation of the growth of rice seedlings. TIS108, a new TIS13 derivative, was found to be a more specific SL biosynthesis inhibitor than TIS13. Treatment of rice seedlings with TIS108 reduced SL levels in both roots and root exudates in a concentration-dependent manner and did not reduce plant height. In addition, root exudates of TIS108-treated rice seedlings stimulated Striga germination less than those of control plants. These results suggest that TIS108 has a potential to be applied in the control of root parasitic weeds germination.",

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AU - Ito, Shinsaku

AU - Umehara, Mikihisa

AU - Hanada, Atsushi

AU - Kitahata, Nobutaka

AU - Hayase, Hiroki

AU - Yamaguchi, Shinjiro

AU - Asami, Tadao

PY - 2011

Y1 - 2011

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Effects of triazole derivatives on strigolactone levels and growth retardation in rice

Abstract

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